ISSN 1662-4009 (online)

ey0019.12-6 | Metabolic syndrome | ESPEYB19

12.6. Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon longitudinal study of parents and children

A Goncalves Soares A, Zimmerman A, Zammit S, Karl A, Halligan SL, Fraser

Journal of the American Heart Association 2021;10(24):e021701. doi: 10.1161/JAHA.121.021701Brief Summary: This population-based birth cohort study identified an association between childhood abuse and higher BMI at age 18 and 25 years, and also hyperinsulinemia and other markers of the MetS at age 25.Comment: Previous studies reported that about one-third of adult candi...

ey0019.14-19 | Reviews | ESPEYB19

14.19. Cytoplasmic DNA: sources, sensing, and role in aging and disease

Miller Karl N , Victorelli Stella G , Salmonowicz Hanna , Dasgupta Nirmalya , Liu Tianhui , Passos Joao F , Adams Peter D

Cell. 2021 Oct 28;184(22):5506–5526. doi: 10.1016/j.cell.2021.09.034Brief Summary: The authors review the function and the underlying molecular mechanisms of 4 major species of endogenous cytoplasmic DNA (cytoDNA) in the development of chronic ageing-associated diseases.In the presence of foreign DNA (e.g. viral infections), innate immunity acts as a defence mec...

ey0018.5-16 | Advances in skeletal biology | ESPEYB18

5.16. Secondary ossification center induces and protects growth plate structure

Xie Meng , Herdina Anna Nele , Estefa Jordi , Medvedeva Ekaterina V , Li Lei , Newton Phillip T , Kotova Svetlana , Shavkuta Boris , Saxena Aditya , Shumate Lauren T , Metscher Brian D , Groszschmidt Karl , Nishimori Shigeki , Akovantseva Anastasia , Usanova Anna P , Kurenkova Anastasiia D , Kumar Anoop , Arregui Irene Linares , Tafforeau Paul , Fried Kaj , Carlstrom Mattias , Simon Andras , Gasser Christian , Kronenberg Henry M , Bastepe Murat , Cooper Kimberly L , Timashev Peter , Sanchez Sophie , Adameyko Igor , Eriksson Anders , Chagin Andrei S

Elife. 2020 Oct 16;9:e55212 Abstract: https://pubmed.ncbi.nlm.nih.gov/33063669/In brief: In some species, growth plate and articular cartilage are not separated by secondary ossification centers. Here, the authors used mathematical modeling, ex vivo models and biophysical tests and indirectly demonstrate that secondary ossification centers evolved in order to protect the g...